Below is a lecture given by Dr. Randy Pausch when he appeared on Oprah.
The full version can also be viewed on YouTube and it is a little over an hour long.
This version is just 10 minutes, though really, it can last a lifetime.

I wrote a whole lot of introspective ramblings here, clicked publish, then changed my mind.

Suffice to say, for the next few weeks I will be attempting to answer a question that has been burning ever since I saw this lecture.

If M had know he was going to die, what would he have said in his 'last lecture'?